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USP15

GENERAL INFORMATION

Gene name

 USP15

Gene description

 Ubiquitin specific peptidase 15

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression at variable levels in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA006428
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006428

GENE INFORMATION

Gene name

 USP15 (HGNC Symbol)

Synonyms

 KIAA0529, UNPH4

Description

 Ubiquitin specific peptidase 15 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

Chromosome

 12

Cytoband

 q14.1

Chromosome location (bp)

 62260338 - 62417431

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135655 (version 83.38)

Entrez gene

 9958

UniProt

 Q9Y4E8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4E8

Antibodypedia

 USP15 antibodies

PROTEIN BROWSER
USP15-001
USP15-002
USP15-003
USP15-006
USP15-011
USP15-014
USP15-017
USP15-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP15-001
ENSP00000258123
ENST00000353364
Q9Y4E8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0035520 [monoubiquitinated protein deubiquitination]
GO:0035616 [histone H2B conserved C-terminal lysine deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0046332 [SMAD binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0061649 [ubiquitinated histone binding]
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 952 aa
109.3 kDa 		No 0
USP15-002
ENSP00000280377
ENST00000280377
Q9Y4E8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0035520 [monoubiquitinated protein deubiquitination]
GO:0035616 [histone H2B conserved C-terminal lysine deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0046332 [SMAD binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0061649 [ubiquitinated histone binding]
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 981 aa
112.4 kDa 		No 0
USP15-003
ENSP00000309240
ENST00000312635
Q9Y4E8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016579 [protein deubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0035520 [monoubiquitinated protein deubiquitination]
GO:0035616 [histone H2B conserved C-terminal lysine deubiquitination]
GO:0042802 [identical protein binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0046332 [SMAD binding]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0061649 [ubiquitinated histone binding]
Show all
 235 aa
27.1 kDa 		No 0
USP15-006
ENSP00000448372
ENST00000549415
H0YI26 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 157 aa
18.2 kDa 		No 0
USP15-011
ENSP00000448393
ENST00000549237
H0YI31 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 240 aa
27.6 kDa 		No 0
USP15-014
ENSP00000446843
ENST00000548836
F8VZG8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 140 aa
16.2 kDa 		No 0
USP15-017
ENSP00000449563
ENST00000546694
F8VVY7 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 106 aa
12.3 kDa 		No 0
USP15-019
ENSP00000447603
ENST00000549523
F8W0H4 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 175 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.