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MDM2

GENERAL INFORMATION

Gene name

 MDM2

Gene description

 MDM2 proto-oncogene, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB000086 , CAB016303
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and cervical cancer (favourable).
Endometrial cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB000086
CAB016303

GENE INFORMATION

Gene name

 MDM2 (HGNC Symbol)

Synonyms

 HDM2, MGC5370

Description

 MDM2 proto-oncogene, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Chromosome

 12

Cytoband

 q15

Chromosome location (bp)

 68808172 - 68850686

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135679 (version 83.38)

Entrez gene

 4193

UniProt

 Q00987 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00987

Antibodypedia

 MDM2 antibodies

PROTEIN BROWSER
«
MDM2-001
MDM2-003
MDM2-004
MDM2-006
MDM2-008
MDM2-009
MDM2-011
MDM2-012
MDM2-013
MDM2-016
MDM2-019
MDM2-022
MDM2-023
MDM2-024
MDM2-026
MDM2-032
MDM2-033
MDM2-201
MDM2-202
MDM2-203
MDM2-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MDM2-001
ENSP00000258149
ENST00000258149
Q00987 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001568 [blood vessel development]
GO:0001974 [blood vessel remodeling]
GO:0002027 [regulation of heart rate]
GO:0002039 [p53 binding]
GO:0003170 [heart valve development]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003283 [atrial septum development]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007089 [traversing start control point of mitotic cell cycle]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0009743 [response to carbohydrate]
GO:0010039 [response to iron ion]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010955 [negative regulation of protein processing]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0018205 [peptidyl-lysine modification]
GO:0019899 [enzyme binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032026 [response to magnesium ion]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0043278 [response to morphine]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045202 [synapse]
GO:0045472 [response to ether]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046677 [response to antibiotic]
GO:0046827 [positive regulation of protein export from nucleus]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048545 [response to steroid hormone]
GO:0060411 [cardiac septum morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071236 [cellular response to antibiotic]
GO:0071301 [cellular response to vitamin B1]
GO:0071310 [cellular response to organic substance]
GO:0071312 [cellular response to alkaloid]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071391 [cellular response to estrogen stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071494 [cellular response to UV-C]
GO:0097110 [scaffold protein binding]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Show all
 497 aa
56 kDa 		No 0
MDM2-003
ENSP00000258148
ENST00000258148
G3XA89 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (Mouse), isoform CRA_g
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 442 aa
50 kDa 		No 0
MDM2-004
ENSP00000377062
ENST00000393410
Q9H4C5 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; p53-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 243 aa
27.3 kDa 		No 0
MDM2-006
ENSP00000299252
ENST00000299252
Q00987 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002039 [p53 binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0018205 [peptidyl-lysine modification]
GO:0019899 [enzyme binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046677 [response to antibiotic]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Show all
 321 aa
36 kDa 		No 0
MDM2-008
ENSP00000353611
ENST00000360430
Q00987 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002039 [p53 binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0018205 [peptidyl-lysine modification]
GO:0019899 [enzyme binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046677 [response to antibiotic]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Show all
 296 aa
33.1 kDa 		No 0
MDM2-009
ENSP00000335096
ENST00000348801
A0A0C4DFR5 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 265 aa
29.7 kDa 		No 0
MDM2-011
ENSP00000430906
ENST00000478070
E5RHE2 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.1 kDa 		No 0
MDM2-012
ENSP00000444430
ENST00000539479
A7UKY0 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 257 aa
28.8 kDa 		No 0
MDM2-013
ENSP00000377068
ENST00000393416
E7EPE2 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 229 aa
26.1 kDa 		No 0
MDM2-016
ENSP00000427828
ENST00000523991
E7EMW5 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 144 aa
16 kDa 		No 0
MDM2-019
ENSP00000430257
ENST00000517852
Q9H4C3 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; p53 binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 130 aa
14.5 kDa 		No 0
MDM2-022
ENSP00000377067
ENST00000393415
A7UKX8 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 256 aa
28.7 kDa 		No 0
MDM2-023
ENSP00000439238
ENST00000543323
A7UKX7 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 118 aa
13.1 kDa 		No 0
MDM2-024
ENSP00000444597
ENST00000545204
F5GZB0 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5.5 kDa 		No 0
MDM2-026
ENSP00000441841
ENST00000544561
F5GWH7 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 70 aa
7.8 kDa 		No 0
MDM2-032
ENSP00000377065
ENST00000393413
Q00987 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002039 [p53 binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0018205 [peptidyl-lysine modification]
GO:0019899 [enzyme binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046677 [response to antibiotic]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Show all
 218 aa
24.5 kDa 		No 0
MDM2-033
ENSP00000266624
ENST00000350057
J3KN53 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; MDM2 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 466 aa
52.4 kDa 		No 0
MDM2-201
ENSP00000348637
ENST00000356290
Q00987 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002039 [p53 binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0018205 [peptidyl-lysine modification]
GO:0019899 [enzyme binding]
GO:0030666 [endocytic vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0034504 [protein localization to nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046677 [response to antibiotic]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Show all
 321 aa
36 kDa 		No 0
MDM2-202
ENSP00000377064
ENST00000393412
Q9H4C5 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; p53-binding protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 243 aa
27.3 kDa 		No 0
MDM2-203
ENSP00000410694
ENST00000428863
Q8TE47 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; MDM2 isoform KB9 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
 243 aa
27.3 kDa 		No 0
MDM2-204
ENSP00000417281
ENST00000462284
J3KN53 [Direct mapping]
E3 ubiquitin-protein ligase Mdm2; MDM2 protein
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
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 466 aa
52.4 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.