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BCO1

GENERAL INFORMATION

Gene name

 BCO1

Gene description

 Beta-carotene oxygenase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, EFO-21, NTERA-2, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 BCO1 (HGNC Symbol)

Synonyms

 BCDO, BCDO1, BCMO, BCMO1, FLJ10730

Description

 Beta-carotene oxygenase 1 (HGNC Symbol)

Entrez gene summary

 Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q23.2

Chromosome location (bp)

 81238448 - 81291142

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135697 (version 83.38)

Entrez gene

 53630

UniProt

 Q9HAY6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAY6

Antibodypedia

 BCO1 antibodies

PROTEIN BROWSER
BCO1-001
BCO1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCO1-001
ENSP00000258168
ENST00000258168
Q9HAY6 [Direct mapping]
Beta,beta-carotene 15,15'-monooxygenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0003834 [beta-carotene 15,15'-monooxygenase activity]
GO:0004497 [monooxygenase activity]
GO:0005829 [cytosol]
GO:0007603 [phototransduction, visible light]
GO:0035238 [vitamin A biosynthetic process]
GO:0042572 [retinol metabolic process]
GO:0042574 [retinal metabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:1901810 [beta-carotene metabolic process]
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 547 aa
62.6 kDa 		No 0
BCO1-003
ENSP00000455219
ENST00000564552
H3BPA2 [Direct mapping]
Beta,beta-carotene 15,15'-monooxygenase
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Predicted intracellular proteins
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 162 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.