Expression of MPHOSPH6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MPHOSPH6

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPHOSPH6
Gene description	M-phase phosphoprotein 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA026948 , CAB003674
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), liver cancer (unfavourable) and prostate cancer (unfavourable).
Ovarian cancer p<0.001 Liver cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026948	CAB003674

GENE INFORMATION
Gene name	MPHOSPH6 (HGNC Symbol)
Synonyms	MPP6
Description	M-phase phosphoprotein 6 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q23.3
Chromosome location (bp)	82147798 - 82170226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135698 (version 83.38)
Entrez gene	10200
UniProt	Q99547 (UniProt - Evidence at protein level)
neXtProt	NX_Q99547
Antibodypedia	MPHOSPH6 antibodies

PROTEIN BROWSER

MPHOSPH6-001	MPHOSPH6-002	MPHOSPH6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPHOSPH6-001 ENSP00000258169 ENST00000258169	Q99547 [Direct mapping] M-phase phosphoprotein 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000176 [nuclear exosome (RNase complex)] GO:0000178 [exosome (RNase complex)] GO:0000460 [maturation of 5.8S rRNA] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	160 aa 19 kDa	No	0
MPHOSPH6-002 ENSP00000454900 ENST00000569021	H3BNK8 [Direct mapping] M-phase phosphoprotein 6; M-phase phosphoprotein 6, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 6.7 kDa	No	0
MPHOSPH6-004 ENSP00000456626 ENST00000563504	H3BSB3 [Direct mapping] M-phase phosphoprotein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] Show all	131 aa 15.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.