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SLC9A5

GENERAL INFORMATION

Gene name

 SLC9A5

Gene description

 Solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-138 MG)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA041004 , HPA041329
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041004
HPA041329

GENE INFORMATION

Gene name

 SLC9A5 (HGNC Symbol)

Synonyms

 NHE5

Description

 Solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 67237683 - 67272190

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135740 (version 83.38)

Entrez gene

 6553

UniProt

 Q14940 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14940

Antibodypedia

 SLC9A5 antibodies

PROTEIN BROWSER
SLC9A5-001
SLC9A5-006
SLC9A5-008
SLC9A5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC9A5-001
ENSP00000299798
ENST00000299798
Q14940 [Direct mapping]
Sodium/hydrogen exchanger 5
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
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GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 896 aa
99 kDa 		Yes >9
SLC9A5-006
ENSP00000462404
ENST00000566626
J3KSB3 [Direct mapping]
Sodium/hydrogen exchanger 5
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0006812 [cation transport]
GO:0015299 [solute:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 273 aa
29.8 kDa 		No 0
SLC9A5-008
ENSP00000462446
ENST00000566345
J3KSE2 [Direct mapping]
Sodium/hydrogen exchanger
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0006812 [cation transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
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 172 aa
18.7 kDa 		No 3
SLC9A5-010
ENSP00000464393
ENST00000567247
J3QRV1 [Direct mapping]
Sodium/hydrogen exchanger 5
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0015299 [solute:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:1902600 [hydrogen ion transmembrane transport]
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 178 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.