We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
AGT
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AGT

Gene description

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (cerebral cortex, liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma with cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA001557 , CAB025798
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

AGT (HGNC Symbol)

Synonyms

SERPINA8

Description

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q42.2

Chromosome location (bp)

230702523 - 230714297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135744 (version 83.38)

Entrez gene

183

UniProt

P01019 (UniProt - Evidence at protein level)

neXtProt

NX_P01019

Antibodypedia

AGT antibodies

PROTEIN BROWSER

AGT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGT-001
ENSP00000355627
ENST00000366667
P01019 [Direct mapping]
Angiotensinogen Angiotensin-1 Angiotensin-2 Angiotensin-3 Angiotensin-4 Angiotensin 1-9 Angiotensin 1-7 Angiotensin 1-5 Angiotensin 1-4
B0ZBE2 [Target identity:100%; Query identity:100%]
Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8); Angiotensinogen (Serpin peptidase inhibitor, clade A, member 8), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001543 [ovarian follicle rupture]
GO:0001558 [regulation of cell growth]
GO:0001568 [blood vessel development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001819 [positive regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001974 [blood vessel remodeling]
GO:0001991 [regulation of systemic arterial blood pressure by circulatory renin-angiotensin]
GO:0001998 [angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure]
GO:0001999 [renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure]
GO:0002003 [angiotensin maturation]
GO:0002016 [regulation of blood volume by renin-angiotensin]
GO:0002018 [renin-angiotensin regulation of aldosterone production]
GO:0002019 [regulation of renal output by angiotensin]
GO:0002027 [regulation of heart rate]
GO:0002034 [regulation of blood vessel size by renin-angiotensin]
GO:0002035 [brain renin-angiotensin system]
GO:0003014 [renal system process]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0003331 [positive regulation of extracellular matrix constituent secretion]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007160 [cell-matrix adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007199 [G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0007588 [excretion]
GO:0008065 [establishment of blood-nerve barrier]
GO:0008083 [growth factor activity]
GO:0008217 [regulation of blood pressure]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009409 [response to cold]
GO:0009651 [response to salt stress]
GO:0010468 [regulation of gene expression]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0014061 [regulation of norepinephrine secretion]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014824 [artery smooth muscle contraction]
GO:0014873 [response to muscle activity involved in regulation of muscle adaptation]
GO:0016176 [superoxide-generating NADPH oxidase activator activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0017080 [sodium channel regulator activity]
GO:0019229 [regulation of vasoconstriction]
GO:0030198 [extracellular matrix organization]
GO:0030308 [negative regulation of cell growth]
GO:0030432 [peristalsis]
GO:0031701 [angiotensin receptor binding]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0031703 [type 2 angiotensin receptor binding]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033864 [positive regulation of NAD(P)H oxidase activity]
GO:0034104 [negative regulation of tissue remodeling]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0035411 [catenin import into nucleus]
GO:0035813 [regulation of renal sodium excretion]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042127 [regulation of cell proliferation]
GO:0042310 [vasoconstriction]
GO:0042311 [vasodilation]
GO:0042445 [hormone metabolic process]
GO:0042756 [drinking behavior]
GO:0042981 [regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045777 [positive regulation of blood pressure]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045909 [positive regulation of vasodilation]
GO:0046622 [positive regulation of organ growth]
GO:0048143 [astrocyte activation]
GO:0048144 [fibroblast proliferation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048659 [smooth muscle cell proliferation]
GO:0050663 [cytokine secretion]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051145 [smooth muscle cell differentiation]
GO:0051387 [negative regulation of neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0051924 [regulation of calcium ion transport]
GO:0051969 [regulation of transmission of nerve impulse]
GO:0061049 [cell growth involved in cardiac muscle cell development]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070062 [extracellular exosome]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070471 [uterine smooth muscle contraction]
GO:0071260 [cellular response to mechanical stimulus]
GO:0072562 [blood microparticle]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901201 [regulation of extracellular matrix assembly]
GO:1902632 [positive regulation of membrane hyperpolarization]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903779 [regulation of cardiac conduction]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
485 aa
53.2 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.