Expression of PCNXL2 in cancer - Summary - The Human Protein Atlas

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PCNXL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCNXL2
Gene description	Pecanex-like 2 (Drosophila)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA013815 , HPA014427
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013815	HPA014427

GENE INFORMATION
Gene name	PCNXL2 (HGNC Symbol)
Synonyms	FLJ11383, KIAA0435
Description	Pecanex-like 2 (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	232983435 - 233295713
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135749 (version 83.38)
Entrez gene	80003
UniProt	A6NKB5 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NKB5
Antibodypedia	PCNXL2 antibodies

PROTEIN BROWSER

PCNXL2-001	PCNXL2-002	PCNXL2-010	PCNXL2-011	PCNXL2-019	PCNXL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCNXL2-001 ENSP00000340759 ENST00000344698	A6NKB5 [Direct mapping] Pecanex-like protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	777 aa 86.6 kDa	No	0
PCNXL2-002 ENSP00000258229 ENST00000258229	A6NKB5 [Direct mapping] Pecanex-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	2137 aa 237.3 kDa	No	>9
PCNXL2-010 ENSP00000430820 ENST00000488780	E7EVZ6 [Direct mapping] Pecanex-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	424 aa 48.3 kDa	Yes	9
PCNXL2-011 ENSP00000428134 ENST00000484347	H0YAV6 [Direct mapping] Pecanex-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	178 aa 21.3 kDa	No	5
PCNXL2-019 ENSP00000429231 ENST00000518351	H0YBD1 [Direct mapping] Pecanex-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	182 aa 20.3 kDa	No	5
PCNXL2-201 ENSP00000394703 ENST00000430153	A0A0A0MSK9 [Direct mapping] Pecanex-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	412 aa 46.9 kDa	Yes	8

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.