Expression of ABCB10 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ABCB10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABCB10
Gene description	ATP-binding cassette, sub-family B (MDR/TAP), member 10
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 3 antibodies. HPA055175 , CAB044063 , CAB044065
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055175	CAB044063	CAB044065

GENE INFORMATION
Gene name	ABCB10 (HGNC Symbol)
Synonyms	EST20237, M-ABC2, MTABC2
Description	ATP-binding cassette, sub-family B (MDR/TAP), member 10 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q42.13
Chromosome location (bp)	229516582 - 229558695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135776 (version 83.38)
Entrez gene	23456
UniProt	Q9NRK6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRK6
Antibodypedia	ABCB10 antibodies

PROTEIN BROWSER

ABCB10-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCB10-001 ENSP00000355637 ENST00000344517	Q9NRK6 [Direct mapping] ATP-binding cassette sub-family B member 10, mitochondrial Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0032592 [integral component of mitochondrial membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0042803 [protein homodimerization activity] GO:0055085 [transmembrane transport] Show all	738 aa 79.1 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.