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Moderate cytoplasmic positivity with occasional nuclear or membranous staining was observed in most cancer tissues. Strong immunoreactivity was observed in occasional cases of hepatocellular carcinomas, ovarian, cervical and endometrial cancers. Skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CEP350 (HGNC Symbol)
Synonyms
CAP350, KIAA0480
Description
Centrosomal protein 350kDa (HGNC Symbol)
Entrez gene summary
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]