Tissue expression of NPL - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPL
Gene description	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NPL (HGNC Symbol)
Synonyms	C1orf13, DHDPS1, NPL1
Description	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	1
Cytoband	q25.3
Chromosome location (bp)	182789293 - 182830384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135838 (version 83.38)
Entrez gene	80896
UniProt	Q9BXD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXD5
Antibodypedia	NPL antibodies

PROTEIN BROWSER

NPL-001	NPL-004	NPL-201	NPL-202	NPL-203	NPL-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPL-001 ENSP00000356524 ENST00000367553	Q9BXD5 [Direct mapping] N-acetylneuraminate lyase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0008747 [N-acetylneuraminate lyase activity] GO:0016829 [lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019262 [N-acetylneuraminate catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	320 aa 35.2 kDa	No	0
NPL-004 ENSP00000356526 ENST00000367555	Q9BXD5 [Direct mapping] N-acetylneuraminate lyase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0008747 [N-acetylneuraminate lyase activity] GO:0016829 [lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019262 [N-acetylneuraminate catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	240 aa 26.8 kDa	No	0
NPL-201 ENSP00000258317 ENST00000258317	Q9BXD5 [Direct mapping] N-acetylneuraminate lyase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0008747 [N-acetylneuraminate lyase activity] GO:0016829 [lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019262 [N-acetylneuraminate catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	320 aa 35.2 kDa	No	0
NPL-202 ENSP00000356523 ENST00000367552	Q9BXD5 [Direct mapping] N-acetylneuraminate lyase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0008747 [N-acetylneuraminate lyase activity] GO:0016829 [lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019262 [N-acetylneuraminate catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	240 aa 26.8 kDa	No	0
NPL-203 ENSP00000356525 ENST00000367554	Q9BXD5 [Direct mapping] N-acetylneuraminate lyase Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0008152 [metabolic process] GO:0008747 [N-acetylneuraminate lyase activity] GO:0016829 [lyase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019262 [N-acetylneuraminate catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	301 aa 33.1 kDa	No	0
NPL-204 ENSP00000482415 ENST00000614468	A0A087WZ70 [Direct mapping] N-acetylneuraminate lyase Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016829 [lyase activity] Show all	230 aa 25.1 kDa	No	0