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Cancer tissues displayed moderate cytoplasmic positivity. Most cases of prostate cancers along with several hepatocellular carcinomas and renal cancers were strongly stained. Skin cancers were weakly stained or negative.
Most cancer tissues showed moderate to strong cytoplasmic positivity with a granular pattern. Many renal cell carcinomas, lymphomas, gliomas and skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
MRPL44 (HGNC Symbol)
Synonyms
FLJ12701, FLJ13990
Description
Mitochondrial ribosomal protein L44 (HGNC Symbol)
Entrez gene summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]