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SERPINE2

GENERAL INFORMATION

Gene name

 SERPINE2

Gene description

 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Expressed in all
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 SERPINE2 (HGNC Symbol)

Synonyms

 GDN, nexin, PI7, PN1, PNI

Description

 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 223975112 - 224039319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135919 (version 83.38)

Entrez gene

 5270

UniProt

 P07093 (UniProt - Evidence at protein level)

neXtProt

 NX_P07093

Antibodypedia

 SERPINE2 antibodies

PROTEIN BROWSER
SERPINE2-001
SERPINE2-002
SERPINE2-003
SERPINE2-005
SERPINE2-007
SERPINE2-008
SERPINE2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERPINE2-001
ENSP00000258405
ENST00000258405
P07093 [Direct mapping]
Glia-derived nexin
A0A024R451 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010955 [negative regulation of protein processing]
GO:0030195 [negative regulation of blood coagulation]
GO:0030334 [regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031091 [platelet alpha granule]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0045861 [negative regulation of proteolysis]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0090331 [negative regulation of platelet aggregation]
GO:1903561 [extracellular vesicle]
Show all
 398 aa
44 kDa 		Yes 0
SERPINE2-002
ENSP00000386412
ENST00000409304
P07093 [Direct mapping]
Glia-derived nexin
A0A024R498 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010955 [negative regulation of protein processing]
GO:0030195 [negative regulation of blood coagulation]
GO:0030334 [regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031091 [platelet alpha granule]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0045861 [negative regulation of proteolysis]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0090331 [negative regulation of platelet aggregation]
GO:1903561 [extracellular vesicle]
Show all
 397 aa
44 kDa 		Yes 0
SERPINE2-003
ENSP00000386969
ENST00000409840
P07093 [Direct mapping]
Glia-derived nexin
A0A024R498 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010955 [negative regulation of protein processing]
GO:0030195 [negative regulation of blood coagulation]
GO:0030334 [regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031091 [platelet alpha granule]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0045861 [negative regulation of proteolysis]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0090331 [negative regulation of platelet aggregation]
GO:1903561 [extracellular vesicle]
Show all
 397 aa
44 kDa 		Yes 0
SERPINE2-005
ENSP00000415786
ENST00000447280
P07093 [Direct mapping]
Glia-derived nexin
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007566 [embryo implantation]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0009611 [response to wounding]
GO:0010466 [negative regulation of peptidase activity]
GO:0010544 [negative regulation of platelet activation]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010766 [negative regulation of sodium ion transport]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010955 [negative regulation of protein processing]
GO:0010976 [positive regulation of neuron projection development]
GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0021683 [cerebellar granular layer morphogenesis]
GO:0030195 [negative regulation of blood coagulation]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031091 [platelet alpha granule]
GO:0031232 [extrinsic component of external side of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0033363 [secretory granule organization]
GO:0042628 [mating plug formation]
GO:0043025 [neuronal cell body]
GO:0045861 [negative regulation of proteolysis]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0050974 [detection of mechanical stimulus involved in sensory perception]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0060384 [innervation]
GO:0061108 [seminal vesicle epithelium development]
GO:0061110 [dense core granule biogenesis]
GO:0090331 [negative regulation of platelet aggregation]
GO:1903561 [extracellular vesicle]
Show all
 409 aa
45.3 kDa 		Yes 0
SERPINE2-007
ENSP00000399655
ENST00000454956
C9K031 [Direct mapping]
Glia-derived nexin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 87 aa
9.5 kDa 		Yes 0
SERPINE2-008
ENSP00000408452
ENST00000432738
C9JN98 [Direct mapping]
Glia-derived nexin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 276 aa
30.5 kDa 		Yes 0
SERPINE2-009
ENSP00000394518
ENST00000423446
C9JRK5 [Direct mapping]
Glia-derived nexin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 42 aa
4.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.