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DNAJB2

GENERAL INFORMATION

Gene name

 DNAJB2

Gene description

 DnaJ (Hsp40) homolog, subfamily B, member 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA036268
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036268

GENE INFORMATION

Gene name

 DNAJB2 (HGNC Symbol)

Synonyms

 CMT2T, HSJ1, HSPF3

Description

 DnaJ (Hsp40) homolog, subfamily B, member 2 (HGNC Symbol)

Entrez gene summary

 This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 219279267 - 219286900

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135924 (version 83.38)

Entrez gene

 3300

UniProt

 P25686 (UniProt - Evidence at protein level)

neXtProt

 NX_P25686

Antibodypedia

 DNAJB2 antibodies

PROTEIN BROWSER
DNAJB2-001
DNAJB2-002
DNAJB2-008
DNAJB2-009
DNAJB2-011
DNAJB2-012
DNAJB2-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJB2-001
ENSP00000338019
ENST00000336576
P25686 [Direct mapping]
DnaJ homolog subfamily B member 2
Q53QD7 [Target identity:100%; Query identity:100%]
DnaJ (Hsp40) homolog, subfamily B, member 2, isoform CRA_a; Putative uncharacterized protein DNAJB2; cDNA, FLJ93128, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 2 (DNAJB2), mRNA
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0016234 [inclusion body]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030544 [Hsp70 protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031593 [polyubiquitin binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042026 [protein refolding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0070628 [proteasome binding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:0090086 [negative regulation of protein deubiquitination]
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 324 aa
35.6 kDa 		No 0
DNAJB2-002
ENSP00000375936
ENST00000392086
P25686 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006457 [protein folding]
GO:0006986 [response to unfolded protein]
GO:0016234 [inclusion body]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0030544 [Hsp70 protein binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031593 [polyubiquitin binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042026 [protein refolding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0070628 [proteasome binding]
GO:0090084 [negative regulation of inclusion body assembly]
GO:0090086 [negative regulation of protein deubiquitination]
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 277 aa
30.6 kDa 		No 0
DNAJB2-008
ENSP00000414796
ENST00000425450
C9JRD2 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 228 aa
25.4 kDa 		No 0
DNAJB2-009
ENSP00000395173
ENST00000421532
E7ETU0 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 132 aa
15.1 kDa 		No 0
DNAJB2-011
ENSP00000392790
ENST00000442681
C9J1G2 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 122 aa
13.8 kDa 		No 0
DNAJB2-012
ENSP00000387951
ENST00000439026
C9JX00 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 148 aa
16.7 kDa 		No 0
DNAJB2-019
ENSP00000375937
ENST00000392087
C9JXB9 [Direct mapping]
DnaJ homolog subfamily B member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 244 aa
26.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.