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Cell line enhanced (CAPAN-2, HaCaT, HDLM-2, U-266/70)
HPA (normal tissue):
Tissue enhanced (skin)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Estimation of protein expression could not be performed. View primary data.
ANTIBODY IHC RELIABILITY
Data reliability description
RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
A majority of cancer cells showed weak cytoplasmic staining or were negative. Occasional moderately stained cases were observed in almost all cancer tissues.
GENE INFORMATION
Gene name
WNT10A
Synonyms
Description
Wingless-type MMTV integration site family, member 10A (HGNC Symbol)
Entrez gene summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]