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CAB39

GENERAL INFORMATION

Gene name

 CAB39

Gene description

 Calcium binding protein 39

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
CAB037112
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB037112

GENE INFORMATION

Gene name

 CAB39 (HGNC Symbol)

Synonyms

 CGI-66, MO25

Description

 Calcium binding protein 39 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 230712845 - 230821075

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135932 (version 83.38)

Entrez gene

 51719

UniProt

 Q9Y376 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y376

Antibodypedia

 CAB39 antibodies

PROTEIN BROWSER
CAB39-001
CAB39-002
CAB39-003
CAB39-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAB39-001
ENSP00000258418
ENST00000258418
Q9Y376 [Direct mapping]
Calcium-binding protein 39
A0A024R496 [Target identity:100%; Query identity:100%]
Calcium binding protein 39, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030295 [protein kinase activator activity]
GO:0032147 [activation of protein kinase activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902554 [serine/threonine protein kinase complex]
GO:2000681 [negative regulation of rubidium ion transport]
GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity]
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 341 aa
39.9 kDa 		No 0
CAB39-002
ENSP00000386238
ENST00000409788
Q9Y376 [Direct mapping]
Calcium-binding protein 39
A0A024R496 [Target identity:100%; Query identity:100%]
Calcium binding protein 39, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030295 [protein kinase activator activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902554 [serine/threonine protein kinase complex]
GO:2000681 [negative regulation of rubidium ion transport]
GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity]
Show all
 341 aa
39.9 kDa 		No 0
CAB39-003
ENSP00000386642
ENST00000410084
Q9Y376 [Direct mapping]
Calcium-binding protein 39
A0A024R496 [Target identity:100%; Query identity:100%]
Calcium binding protein 39, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0008286 [insulin receptor signaling pathway]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030295 [protein kinase activator activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0070062 [extracellular exosome]
GO:0071476 [cellular hypotonic response]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:1901017 [negative regulation of potassium ion transmembrane transporter activity]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1902554 [serine/threonine protein kinase complex]
GO:2000681 [negative regulation of rubidium ion transport]
GO:2000687 [negative regulation of rubidium ion transmembrane transporter activity]
Show all
 341 aa
39.9 kDa 		No 0
CAB39-201
ENSP00000483459
ENST00000614925
A0A087X0K1 [Direct mapping]
Calcium-binding protein 39
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
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 339 aa
39.5 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.