Fields »
ABOUT
HELP
BLOG
ARHGEF4

GENERAL INFORMATION

Gene name

 ARHGEF4

Gene description

 Rho guanine nucleotide exchange factor (GEF) 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HaCaT, hTCEpi, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues most abundant in neurons of CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018267
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (favourable).
Testis cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018267

GENE INFORMATION

Gene name

 ARHGEF4 (HGNC Symbol)

Synonyms

 ASEF, KIAA1112, STM6

Description

 Rho guanine nucleotide exchange factor (GEF) 4 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]

Chromosome

 2

Cytoband

 q21.1

Chromosome location (bp)

 130836916 - 131047263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136002 (version 83.38)

Entrez gene

 50649

UniProt

 Q9NR80 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR80

Antibodypedia

 ARHGEF4 antibodies

PROTEIN BROWSER
ARHGEF4-001
ARHGEF4-002
ARHGEF4-003
ARHGEF4-004
ARHGEF4-005
ARHGEF4-009
ARHGEF4-012
ARHGEF4-201
ARHGEF4-202
ARHGEF4-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF4-001
ENSP00000316845
ENST00000326016
Q9NR80 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 690 aa
79.1 kDa 		No 0
ARHGEF4-002
ENSP00000432267
ENST00000525839
Q9NR80 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 670 aa
76.4 kDa 		No 0
ARHGEF4-003
ENSP00000386794
ENST00000409359
E7EV07 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1014 aa
108.2 kDa 		No 0
ARHGEF4-004
ENSP00000389661
ENST00000438985
H0Y451 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 372 aa
40.9 kDa 		No 0
ARHGEF4-005
ENSP00000387285
ENST00000409303
E9PEM0 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 630 aa
71.8 kDa 		No 0
ARHGEF4-009
ENSP00000348017
ENST00000355771
Q9NR80 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019904 [protein domain specific binding]
GO:0030032 [lamellipodium assembly]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046847 [filopodium assembly]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 619 aa
71.1 kDa 		No 0
ARHGEF4-012
ENSP00000432301
ENST00000532720
H0YCT6 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 287 aa
33.2 kDa 		No 0
ARHGEF4-201
ENSP00000376680
ENST00000392953
A0A0C4DFY6 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 720 aa
81.8 kDa 		Yes 0
ARHGEF4-202
ENSP00000398455
ENST00000428230
A4QPB6 [Direct mapping]
ARHGEF4 protein; Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 192 aa
21.8 kDa 		No 0
ARHGEF4-203
ENSP00000483548
ENST00000611048
E9PEM0 [Direct mapping]
Rho guanine nucleotide exchange factor 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 630 aa
71.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.