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ALDH1L2

GENERAL INFORMATION

Gene name

 ALDH1L2

Gene description

 Aldehyde dehydrogenase 1 family, member L2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results.

Reliability score

 Uncertain based on 1 antibody.
HPA039481
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039481

GENE INFORMATION

Gene name

 ALDH1L2 (HGNC Symbol)

Synonyms

 FLJ38508, mtFDH

Description

 Aldehyde dehydrogenase 1 family, member L2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 105019784 - 105084577

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136010 (version 83.38)

Entrez gene

 160428

UniProt

 Q3SY69 (UniProt - Evidence at protein level)

neXtProt

 NX_Q3SY69

Antibodypedia

 ALDH1L2 antibodies

PROTEIN BROWSER
ALDH1L2-001
ALDH1L2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1L2-001
ENSP00000258494
ENST00000258494
Q3SY69 [Direct mapping]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006730 [one-carbon metabolic process]
GO:0008152 [metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009258 [10-formyltetrahydrofolate catabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 923 aa
101.7 kDa 		No 0
ALDH1L2-005
ENSP00000447464
ENST00000548418
H0YHN9 [Direct mapping]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016155 [formyltetrahydrofolate dehydrogenase activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 92 aa
10.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.