Expression of SLC41A2 in cancer - Summary - The Human Protein Atlas

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SLC41A2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC41A2
Gene description	Solute carrier family 41 (magnesium transporter), member 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA038658
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038658

GENE INFORMATION
Gene name	SLC41A2 (HGNC Symbol)
Synonyms	DKFZP434K0427
Description	Solute carrier family 41 (magnesium transporter), member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	104802553 - 104958744
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136052 (version 83.38)
Entrez gene	84102
UniProt	Q96JW4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96JW4
Antibodypedia	SLC41A2 antibodies

PROTEIN BROWSER

SLC41A2-001	SLC41A2-002	SLC41A2-003	SLC41A2-004	SLC41A2-005	SLC41A2-006	SLC41A2-007	SLC41A2-008	SLC41A2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC41A2-001 ENSP00000258538 ENST00000258538	Q96JW4 [Direct mapping] Solute carrier family 41 member 2 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	573 aa 62.5 kDa	No	>9
SLC41A2-002 ENSP00000391377 ENST00000437220	H7BZT9 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	149 aa 15.9 kDa	No	3
SLC41A2-003 ENSP00000414526 ENST00000449866	C9JKF2 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		94 aa 10.6 kDa	No	0
SLC41A2-004 ENSP00000396297 ENST00000417469	C9JDQ2 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		46 aa 4.9 kDa	No	0
SLC41A2-005 ENSP00000395550 ENST00000433540	C9JIL4 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		76 aa 8.4 kDa	No	0
SLC41A2-006 ENSP00000410625 ENST00000432951	C9J2P6 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		12 aa 1.3 kDa	No	0
SLC41A2-007 ENSP00000397315 ENST00000424946	C9JA64 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		72 aa 7.9 kDa	No	0
SLC41A2-008 ENSP00000396429 ENST00000415674	C9JCR2 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		143 aa 16 kDa	No	0
SLC41A2-009 ENSP00000407898 ENST00000411411	C9JYJ7 [Direct mapping] Solute carrier family 41 member 2 Show all	Predicted intracellular proteins Show all		122 aa 13.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.