Cell atlas - NEK3 - The Human Protein Atlas

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NEK3

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules

Human cell
	Microtubules

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GENERAL INFORMATION
Gene name	NEK3
Gene description	NIMA-related kinase 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043230
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules.

Main location

Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043230	HEK 293	Microtubules
	HPA043230	Hep G2	Microtubules
	HPA043230	U-2 OS	Microtubules

GENE INFORMATION
Gene name	NEK3 (HGNC Symbol)
Synonyms	HSPK36, MGC29949
Description	NIMA-related kinase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	52132639 - 52159861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136098 (version 83.38)
Entrez gene	4752
UniProt	P51956 (UniProt - Evidence at protein level)
neXtProt	NX_P51956
Antibodypedia	NEK3 antibodies

PROTEIN BROWSER

NEK3-001	NEK3-003	NEK3-005	NEK3-008	NEK3-201	NEK3-202	NEK3-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK3-001 ENSP00000480328 ENST00000610828	P51956 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0030424 [axon] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	506 aa 57.7 kDa	No	0
NEK3-003 ENSP00000481533 ENST00000620675	A0A087WY58 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	497 aa 56.7 kDa	No	0
NEK3-005 ENSP00000449679 ENST00000550841	F8VV00 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	58 aa 6.7 kDa	No	0
NEK3-008 ENSP00000483058 ENST00000618856	A0A087X030 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0006468 [protein phosphorylation] Show all	182 aa 20.4 kDa	No	0
NEK3-201 ENSP00000484086 ENST00000611833	P51956 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0030424 [axon] GO:0046872 [metal ion binding] GO:0051301 [cell division] Show all	489 aa 55.9 kDa	No	0
NEK3-202 ENSP00000484443 ENST00000618534	P51956 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0030010 [establishment of cell polarity] GO:0030424 [axon] GO:0046872 [metal ion binding] GO:0048812 [neuron projection morphogenesis] GO:0051301 [cell division] GO:0090043 [regulation of tubulin deacetylation] Show all	506 aa 57.7 kDa	No	0
NEK3-203 ENSP00000487230 ENST00000629912	F8VTT4 [Direct mapping] Serine/threonine-protein kinase Nek3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	46 aa 5.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.