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VPS36

GENERAL INFORMATION

Gene name

 VPS36

Gene description

 Vacuolar protein sorting 36 homolog (S. cerevisiae)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039734 , HPA043947
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039734
HPA043947

GENE INFORMATION

Gene name

 VPS36 (HGNC Symbol)

Synonyms

 C13orf9, CGI-145, Eap45

Description

 Vacuolar protein sorting 36 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

Chromosome

 13

Cytoband

 q14.3

Chromosome location (bp)

 52412602 - 52450628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136100 (version 83.38)

Entrez gene

 51028

UniProt

 Q86VN1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86VN1

Antibodypedia

 VPS36 antibodies

PROTEIN BROWSER
VPS36-001
VPS36-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS36-001
ENSP00000367299
ENST00000378060
Q86VN1 [Direct mapping]
Vacuolar protein-sorting-associated protein 36
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000814 [ESCRT II complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0016197 [endosomal transport]
GO:0031902 [late endosome membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0043130 [ubiquitin binding]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 386 aa
43.8 kDa 		No 0
VPS36-201
ENSP00000484968
ENST00000611132
Q86VN1 [Direct mapping]
Vacuolar protein-sorting-associated protein 36
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000814 [ESCRT II complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008022 [protein C-terminus binding]
GO:0016197 [endosomal transport]
GO:0031902 [late endosome membrane]
GO:0032266 [phosphatidylinositol-3-phosphate binding]
GO:0043130 [ubiquitin binding]
GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 328 aa
37 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.