Expression of BORA in cancer - Summary - The Human Protein Atlas

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BORA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BORA
Gene description	Bora, aurora kinase A activator
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040866

GENE INFORMATION
Gene name	BORA (HGNC Symbol)
Synonyms	C13orf34, FLJ22624
Description	Bora, aurora kinase A activator (HGNC Symbol)
Entrez gene summary	BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Chromosome	13
Cytoband	q21.33
Chromosome location (bp)	72727749 - 72756198
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136122 (version 83.38)
Entrez gene	79866
UniProt	Q6PGQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PGQ7
Antibodypedia	BORA antibodies

PROTEIN BROWSER

BORA-001	BORA-002	BORA-005	BORA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BORA-001 ENSP00000375082 ENST00000390667	B5LMG6 [Direct mapping] Aurora borealis; FLJ22624 protein, isoform CRA_a; Protein aurora borealis Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		619 aa 67.7 kDa	No	0
BORA-002 ENSP00000367045 ENST00000377814	H3BLY2 [Direct mapping] Protein aurora borealis Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		214 aa 23.5 kDa	No	0
BORA-005 ENSP00000367046 ENST00000377815	Q6PGQ7 [Direct mapping] Protein aurora borealis Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007088 [regulation of mitotic nuclear division] GO:0019901 [protein kinase binding] GO:0032880 [regulation of protein localization] GO:0051301 [cell division] GO:0060236 [regulation of mitotic spindle organization] Show all	489 aa 53.4 kDa	No	0
BORA-201 ENSP00000479266 ENST00000613797	A0A087WV86 [Direct mapping] Protein aurora borealis Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0072687 [meiotic spindle] Show all	634 aa 69.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.