Expression of LRCH1 in cancer - Summary - The Human Protein Atlas

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LRCH1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRCH1
Gene description	Leucine-rich repeats and calponin homology (CH) domain containing 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA021536
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), ovarian cancer (unfavourable), cervical cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Cervical cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021536

GENE INFORMATION
Gene name	LRCH1 (HGNC Symbol)
Synonyms	CHDC1, KIAA1016
Description	Leucine-rich repeats and calponin homology (CH) domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
Chromosome	13
Cytoband
Chromosome location (bp)	46553168 - 46753040
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136141 (version 83.38)
Entrez gene	23143
UniProt	Q9Y2L9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2L9
Antibodypedia	LRCH1 antibodies

PROTEIN BROWSER

LRCH1-001	LRCH1-002	LRCH1-004	LRCH1-005	LRCH1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRCH1-001 ENSP00000374448 ENST00000389798	Q9Y2L9 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	728 aa 80.9 kDa	No	1
LRCH1-002 ENSP00000308493 ENST00000311191	Q9Y2L9 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	696 aa 77.2 kDa	No	0
LRCH1-004 ENSP00000374447 ENST00000389797	Q9Y2L9 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	763 aa 84.6 kDa	No	1
LRCH1-005 ENSP00000417121 ENST00000463929	C9J5B8 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.9 kDa	No	0
LRCH1-006 ENSP00000419256 ENST00000478412	C9JWE0 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.