Cell atlas - RCBTB2 - The Human Protein Atlas

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RCBTB2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleus

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RCBTB2
Gene description	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & the Golgi apparatus.
RNA cell category	Cell line enriched (MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040242
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & the Golgi apparatus.

Main location

Nucleus (approved), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040242	BJ	Nucleus
	HPA040242	BJ	Golgi apparatus
	HPA040242	SiHa	Nucleus
	HPA040242	SiHa	Golgi apparatus
	HPA040242	U-2 OS	No staining

GENE INFORMATION
Gene name	RCBTB2 (HGNC Symbol)
Synonyms	CHC1L
Description	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	48488959 - 48533256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136161 (version 83.38)
Entrez gene	1102
UniProt	O95199 (UniProt - Evidence at protein level)
neXtProt	NX_O95199
Antibodypedia	RCBTB2 antibodies

PROTEIN BROWSER

RCBTB2-001	RCBTB2-201	RCBTB2-202	RCBTB2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCBTB2-001 ENSP00000345144 ENST00000344532	O95199 [Direct mapping] RCC1 and BTB domain-containing protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005087 [Ran guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	551 aa 60.3 kDa	No	0
RCBTB2-201 ENSP00000389910 ENST00000430805	B4DWG0 [Direct mapping] RCC1 and BTB domain-containing protein 2; cDNA FLJ58545, highly similar to RCC1 and BTB domain-containing protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0005515 [protein binding] Show all	556 aa 61 kDa	No	0
RCBTB2-202 ENSP00000443862 ENST00000544492	B4E372 [Direct mapping] RCC1 and BTB domain-containing protein 2; cDNA FLJ54251, highly similar to RCC1 and BTB domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	277 aa 31 kDa	No	0
RCBTB2-203 ENSP00000443904 ENST00000544904	O95199 [Direct mapping] RCC1 and BTB domain-containing protein 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005087 [Ran guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	527 aa 57.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.