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LCP1

GENERAL INFORMATION

Gene name

 LCP1

Gene description

 Lymphocyte cytosolic protein 1 (L-plastin)

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-698)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019493 , CAB020673
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA019493
CAB020673

GENE INFORMATION

Gene name

 LCP1 (HGNC Symbol)

Synonyms

 CP64, L-PLASTIN, LC64P, PLS2

Description

 Lymphocyte cytosolic protein 1 (L-plastin) (HGNC Symbol)

Entrez gene summary

 Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q14.13

Chromosome location (bp)

 46125920 - 46211871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136167 (version 83.38)

Entrez gene

 3936

UniProt

 P13796 (UniProt - Evidence at protein level)

neXtProt

 NX_P13796

Antibodypedia

 LCP1 antibodies

PROTEIN BROWSER
LCP1-001
LCP1-005
LCP1-006
LCP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LCP1-001
ENSP00000408052
ENST00000416500
Q5TBN3 [Direct mapping]
Plastin-2
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
Show all
 246 aa
27.3 kDa 		No 0
LCP1-005
ENSP00000402157
ENST00000442275
Q5TBN5 [Direct mapping]
Plastin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
Show all
 66 aa
7.4 kDa 		No 0
LCP1-006
ENSP00000381581
ENST00000398576
P13796 [Direct mapping]
Plastin-2
A0A024RDT4 [Target identity:100%; Query identity:100%]
Lymphocyte cytosolic protein 1 (L-plastin), isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0001891 [phagocytic cup]
GO:0002102 [podosome]
GO:0002286 [T cell activation involved in immune response]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0022617 [extracellular matrix disassembly]
GO:0030175 [filopodium]
GO:0031100 [organ regeneration]
GO:0032432 [actin filament bundle]
GO:0032587 [ruffle membrane]
GO:0033157 [regulation of intracellular protein transport]
GO:0042802 [identical protein binding]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071803 [positive regulation of podosome assembly]
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 627 aa
70.3 kDa 		No 0
LCP1-201
ENSP00000315757
ENST00000323076
P13796 [Direct mapping]
Plastin-2
A0A024RDT4 [Target identity:100%; Query identity:100%]
Lymphocyte cytosolic protein 1 (L-plastin), isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0002102 [podosome]
GO:0002286 [T cell activation involved in immune response]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0010737 [protein kinase A signaling]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0022617 [extracellular matrix disassembly]
GO:0030175 [filopodium]
GO:0032432 [actin filament bundle]
GO:0032587 [ruffle membrane]
GO:0033157 [regulation of intracellular protein transport]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071803 [positive regulation of podosome assembly]
Show all
 627 aa
70.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.