Expression of SCRN1 in cancer - Summary - The Human Protein Atlas

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SCRN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SCRN1
Gene description	Secernin 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA024517
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), endometrial cancer (unfavourable), urothelial cancer (unfavourable), ovarian cancer (unfavourable), breast cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Urothelial cancer p<0.001 Ovarian cancer p<0.001 Breast cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024517

GENE INFORMATION
Gene name	SCRN1 (HGNC Symbol)
Synonyms	KIAA0193
Description	Secernin 1 (HGNC Symbol)
Entrez gene summary	This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	29920103 - 29990289
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136193 (version 83.38)
Entrez gene	9805
UniProt	Q12765 (UniProt - Evidence at protein level)
neXtProt	NX_Q12765
Antibodypedia	SCRN1 antibodies

PROTEIN BROWSER

SCRN1-001	SCRN1-002	SCRN1-003	SCRN1-005	SCRN1-006	SCRN1-007	SCRN1-009	SCRN1-201	SCRN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCRN1-001 ENSP00000242059 ENST00000242059	Q12765 [Direct mapping] Secernin-1 A0A090N7T9 [Target identity:100%; Query identity:100%] Secernin 1 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] GO:0031965 [nuclear membrane] Show all	414 aa 46.4 kDa	No	0
SCRN1-002 ENSP00000386872 ENST00000409497	Q12765 [Direct mapping] Secernin-1 A0A090N7T9 [Target identity:100%; Query identity:100%] Secernin 1 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] GO:0031965 [nuclear membrane] Show all	414 aa 46.4 kDa	No	0
SCRN1-003 ENSP00000413184 ENST00000421434	C9K052 [Direct mapping] Secernin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] Show all	245 aa 27.1 kDa	No	0
SCRN1-005 ENSP00000388942 ENST00000434476	Q12765 [Direct mapping] Secernin-1 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] GO:0031965 [nuclear membrane] Show all	434 aa 48.7 kDa	No	0
SCRN1-006 ENSP00000406289 ENST00000438497	C9J7U9 [Direct mapping] Secernin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006887 [exocytosis] Show all	141 aa 15.3 kDa	No	0
SCRN1-007 ENSP00000387052 ENST00000409570	B8ZZP4 [Direct mapping] Secernin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006887 [exocytosis] Show all	140 aa 15.6 kDa	No	0
SCRN1-009 ENSP00000414245 ENST00000425819	Q12765 [Direct mapping] Secernin-1 A0A024RA21 [Target identity:100%; Query identity:100%] Secernin 1, isoform CRA_a Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] GO:0031965 [nuclear membrane] Show all	346 aa 38.9 kDa	No	0
SCRN1-201 ENSP00000409068 ENST00000426154	Q12765 [Direct mapping] Secernin-1 A0A090N7T9 [Target identity:100%; Query identity:100%] Secernin 1 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006887 [exocytosis] GO:0016805 [dipeptidase activity] GO:0031965 [nuclear membrane] Show all	414 aa 46.4 kDa	No	0
SCRN1-202 ENSP00000486034 ENST00000631335	B8ZZP4 [Direct mapping] Secernin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0006887 [exocytosis] Show all	140 aa 15.6 kDa	No	0

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