Expression of CHST12 in cancer - Summary - The Human Protein Atlas

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CHST12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHST12
Gene description	Carbohydrate (chondroitin 4) sulfotransferase 12
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA041680
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041680

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Moderate cytoplasmic and nuclear immunoreactivity was observed in carcinoids, prostate, colorectal, breast, thyroid cancers along with a few ovarian and endometrial cancers. Remaining cancers were in general weakly stained or negative.

GENE INFORMATION
Gene name	CHST12 (HGNC Symbol)
Synonyms	C4S-2, C4ST2
Description	Carbohydrate (chondroitin 4) sulfotransferase 12 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	2403560 - 2448483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136213 (version 83.38)
Entrez gene	55501
UniProt	Q9NRB3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRB3
Antibodypedia	CHST12 antibodies

PROTEIN BROWSER

CHST12-002	CHST12-003	CHST12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST12-002 ENSP00000258711 ENST00000258711	Q9NRB3 [Direct mapping] Carbohydrate sulfotransferase 12 A0A024R860 [Target identity:100%; Query identity:100%] Carbohydrate (Chondroitin 4) sulfotransferase 12, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030173 [integral component of Golgi membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047756 [chondroitin 4-sulfotransferase activity] GO:0050656 [3'-phosphoadenosine 5'-phosphosulfate binding] Show all	414 aa 48.4 kDa	No	1
CHST12-003 ENSP00000411207 ENST00000432336	C9J991 [Direct mapping] Carbohydrate sulfotransferase 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	245 aa 28.2 kDa	No	1
CHST12-201 ENSP00000481912 ENST00000618655	Q9NRB3 [Direct mapping] Carbohydrate sulfotransferase 12 A0A024R860 [Target identity:100%; Query identity:100%] Carbohydrate (Chondroitin 4) sulfotransferase 12, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005975 [carbohydrate metabolic process] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0030173 [integral component of Golgi membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047756 [chondroitin 4-sulfotransferase activity] GO:0050656 [3'-phosphoadenosine 5'-phosphosulfate binding] Show all	414 aa 48.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.