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IGF2BP3

GENERAL INFORMATION

Gene name

 IGF2BP3

Gene description

 Insulin-like growth factor 2 mRNA binding protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression most abundant in testis, CNS and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA002037
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002037

GENE INFORMATION

Gene name

 IGF2BP3 (HGNC Symbol)

Synonyms

 CT98, IMP-3, IMP3

Description

 Insulin-like growth factor 2 mRNA binding protein 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p15.3

Chromosome location (bp)

 23310209 - 23470467

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136231 (version 83.38)

Entrez gene

 10643

UniProt

 O00425 (UniProt - Evidence at protein level)

neXtProt

 NX_O00425

Antibodypedia

 IGF2BP3 antibodies

PROTEIN BROWSER
IGF2BP3-001
IGF2BP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGF2BP3-001
ENSP00000258729
ENST00000258729
O00425 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0051028 [mRNA transport]
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 579 aa
63.7 kDa 		No 0
IGF2BP3-201
ENSP00000480267
ENST00000619562
O00425 [Direct mapping]
Insulin-like growth factor 2 mRNA-binding protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010467 [gene expression]
GO:0017148 [negative regulation of translation]
GO:0042035 [regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0045182 [translation regulator activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0051028 [mRNA transport]
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 198 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.