Expression of GPNMB in cancer - Summary - The Human Protein Atlas

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GPNMB

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GPNMB
Gene description	Glycoprotein (transmembrane) nmb
Protein class	Disease related genes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+, RT4, SK-MEL-30)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GPNMB (HGNC Symbol)
Synonyms	HGFIN, NMB
Description	Glycoprotein (transmembrane) nmb (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	23235967 - 23275108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136235 (version 83.38)
Entrez gene	10457
UniProt	Q14956 (UniProt - Evidence at protein level)
neXtProt	NX_Q14956
Antibodypedia	GPNMB antibodies

PROTEIN BROWSER

GPNMB-001	GPNMB-002	GPNMB-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPNMB-001 ENSP00000258733 ENST00000258733	Q14956 [Direct mapping] Transmembrane glycoprotein NMB A0A024RA55 [Target identity:100%; Query identity:100%] Glycoprotein (Transmembrane) nmb, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0042470 [melanosome] Show all	560 aa 62.6 kDa	Yes	1
GPNMB-002 ENSP00000371420 ENST00000381990	Q14956 [Direct mapping] Transmembrane glycoprotein NMB Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0005178 [integrin binding] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030282 [bone mineralization] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0042470 [melanosome] Show all	572 aa 63.9 kDa	Yes	1
GPNMB-007 ENSP00000386476 ENST00000409458	Q96F58 [Direct mapping] GPNMB protein; Glycoprotein (Transmembrane) nmb; Glycoprotein (Transmembrane) nmb, isoform CRA_a; Putative uncharacterized protein GPNMB; Transmembrane glycoprotein NMB Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	206 aa 23.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.