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Extracellular deposits and cytoplasmic expression in subsets of lymphoid cells in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Tumor tissues were generally negative. Extracellular material and stromal inflammatory cells in a few malignancies were stained.
GENE INFORMATION
Gene name
IL6 (HGNC Symbol)
Synonyms
BSF2, HGF, HSF, IFNB2, IL-6
Description
Interleukin 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]