Expression of ZDHHC4 in cancer - Summary - The Human Protein Atlas

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ZDHHC4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZDHHC4
Gene description	Zinc finger, DHHC-type containing 4
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA032124
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (unfavourable), urothelial cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA032124

GENE INFORMATION
Gene name	ZDHHC4 (HGNC Symbol)
Synonyms	FLJ10479, ZNF374
Description	Zinc finger, DHHC-type containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	6577434 - 6589374
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136247 (version 83.38)
Entrez gene	55146
UniProt	Q9NPG8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NPG8
Antibodypedia	ZDHHC4 antibodies

PROTEIN BROWSER

ZDHHC4-001	ZDHHC4-002	ZDHHC4-003	ZDHHC4-004	ZDHHC4-006	ZDHHC4-201	ZDHHC4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZDHHC4-001 ENSP00000379934 ENST00000396706	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5
ZDHHC4-002 ENSP00000385027 ENST00000405731	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5
ZDHHC4-003 ENSP00000379937 ENST00000396709	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5
ZDHHC4-004 ENSP00000418496 ENST00000483589	C9J5I9 [Direct mapping] Probable palmitoyltransferase ZDHHC4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	165 aa 19 kDa	No	2
ZDHHC4-006 ENSP00000337475 ENST00000335965	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5
ZDHHC4-201 ENSP00000379935 ENST00000396707	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5
ZDHHC4-202 ENSP00000379941 ENST00000396713	Q9NPG8 [Direct mapping] Probable palmitoyltransferase ZDHHC4 A0A024QZS8 [Target identity:100%; Query identity:100%] Palmitoyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006612 [protein targeting to membrane] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0018230 [peptidyl-L-cysteine S-palmitoylation] GO:0019706 [protein-cysteine S-palmitoyltransferase activity] Show all	344 aa 39.8 kDa	No	5

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The Human Protein Atlas

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