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DGKB

GENERAL INFORMATION

Gene name

 DGKB

Gene description

 Diacylglycerol kinase, beta 90kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (AF22, SCLC-21H, SH-SY5Y, U-266/70)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DGKB (HGNC Symbol)

Synonyms

 DAGK2, DGK, DGK-BETA, KIAA0718

Description

 Diacylglycerol kinase, beta 90kDa (HGNC Symbol)

Entrez gene summary

 Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p21.2

Chromosome location (bp)

 14145049 - 14974777

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136267 (version 83.38)

Entrez gene

 1607

UniProt

 Q9Y6T7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y6T7

Antibodypedia

 DGKB antibodies

PROTEIN BROWSER
DGKB-001
DGKB-002
DGKB-005
DGKB-011
DGKB-013
DGKB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKB-001
ENSP00000385780
ENST00000403951
Q9Y6T7 [Direct mapping]
Diacylglycerol kinase beta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
Show all
 804 aa
90.6 kDa 		No 0
DGKB-002
ENSP00000386066
ENST00000406247
Q9Y6T7 [Direct mapping]
Diacylglycerol kinase beta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
Show all
 773 aa
87.1 kDa 		No 0
DGKB-005
ENSP00000405569
ENST00000437998
C9JA18 [Direct mapping]
Diacylglycerol kinase beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 75 aa
8.8 kDa 		No 0
DGKB-011
ENSP00000385031
ENST00000407950
B5MCD5 [Direct mapping]
Diacylglycerol kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 796 aa
89.6 kDa 		No 0
DGKB-013
ENSP00000384909
ENST00000402815
B5MBY2 [Direct mapping]
Diacylglycerol kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 803 aa
90.5 kDa 		No 0
DGKB-201
ENSP00000382260
ENST00000399322
Q9Y6T7 [Direct mapping]
Diacylglycerol kinase beta
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005509 [calcium ion binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
Show all
 804 aa
90.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.