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MMD2
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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

MMD2

Gene description

Monocyte to macrophage differentiation-associated 2

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

MMD2 (HGNC Symbol)

Synonyms

PAQR10

Description

Monocyte to macrophage differentiation-associated 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Chromosome

7

Cytoband

p22.1

Chromosome location (bp)

4905989 - 4959213

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136297 (version 83.38)

Entrez gene

221938

UniProt

Q8IY49 (UniProt - Evidence at protein level)

neXtProt

NX_Q8IY49

Antibodypedia

MMD2 antibodies

PROTEIN BROWSER

MMD2-001
MMD2-002
MMD2-003
MMD2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMD2-001
ENSP00000384690
ENST00000404774
Q8IY49 [Direct mapping]
Monocyte to macrophage differentiation factor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0032880 [regulation of protein localization]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
Show all
270 aa
31.3 kDa
No 7
MMD2-002
ENSP00000384141
ENST00000401401
Q8IY49 [Direct mapping]
Monocyte to macrophage differentiation factor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0019835 [cytolysis]
GO:0032880 [regulation of protein localization]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
Show all
246 aa
28.8 kDa
No 7
MMD2-003
ENSP00000385963
ENST00000406755
Q8IY49 [Direct mapping]
Monocyte to macrophage differentiation factor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0032880 [regulation of protein localization]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
Show all
193 aa
22.7 kDa
No 5
MMD2-201
ENSP00000484193
ENST00000612910
Q8IY49 [Direct mapping]
Monocyte to macrophage differentiation factor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0032880 [regulation of protein localization]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
Show all
193 aa
22.7 kDa
No 5

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