Cell atlas - CIB2 - The Human Protein Atlas

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CIB2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	CIB2
Gene description	Calcium and integrin binding family member 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SH-SY5Y, SCLC-21H, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, SCLC-21H, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	CIB2 (HGNC Symbol)
Synonyms	DFNB48, KIP2, USH1J
Description	Calcium and integrin binding family member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78104606 - 78131544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136425 (version 83.38)
Entrez gene	10518
UniProt	O75838 (UniProt - Evidence at protein level)
neXtProt	NX_O75838
Antibodypedia	CIB2 antibodies

PROTEIN BROWSER

CIB2-001	CIB2-002	CIB2-003	CIB2-005	CIB2-006	CIB2-008	CIB2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIB2-001 ENSP00000258930 ENST00000258930	O75838 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0000287 [magnesium ion binding] GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0005178 [integrin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005927 [muscle tendon junction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0031594 [neuromuscular junction] GO:0032403 [protein complex binding] GO:0032420 [stereocilium] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0045494 [photoreceptor cell maintenance] GO:0055074 [calcium ion homeostasis] GO:0071318 [cellular response to ATP] GO:0072562 [blood microparticle] Show all	187 aa 21.6 kDa	No	0
CIB2-002 ENSP00000442459 ENST00000539011	O75838 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0000287 [magnesium ion binding] GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0032420 [stereocilium] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0045494 [photoreceptor cell maintenance] GO:0055074 [calcium ion homeostasis] GO:0071318 [cellular response to ATP] GO:0072562 [blood microparticle] Show all	144 aa 16.5 kDa	No	0
CIB2-003 ENSP00000453377 ENST00000559054	H0YLX3 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	55 aa 6.4 kDa	No	0
CIB2-005 ENSP00000452752 ENST00000560618	H0YKC8 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	167 aa 19 kDa	No	0
CIB2-006 ENSP00000453488 ENST00000557846	O75838 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0000287 [magnesium ion binding] GO:0001750 [photoreceptor outer segment] GO:0001917 [photoreceptor inner segment] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0032420 [stereocilium] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0045494 [photoreceptor cell maintenance] GO:0055074 [calcium ion homeostasis] GO:0071318 [cellular response to ATP] GO:0072562 [blood microparticle] Show all	138 aa 15.8 kDa	No	0
CIB2-008 ENSP00000453256 ENST00000561190	H0YLL7 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	126 aa 14.5 kDa	No	0
CIB2-009 ENSP00000452980 ENST00000559645	H0YKX8 [Direct mapping] Calcium and integrin-binding family member 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	147 aa 16.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.