Expression of CSH1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CSH1

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CSH1
Gene description	Chorionic somatomammotropin hormone 1 (placental lactogen)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA043715 , CAB026374
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043715	CAB026374

GENE INFORMATION
Gene name	CSH1 (HGNC Symbol)
Synonyms	CSA, CSMT, FLJ75407, hCS-A, PL
Description	Chorionic somatomammotropin hormone 1 (placental lactogen) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63894909 - 63896661
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136488 (version 83.38)
Entrez gene	1442
UniProt	P0DML2 (UniProt - Evidence at protein level)
neXtProt	NX_P0DML2
Antibodypedia	CSH1 antibodies

PROTEIN BROWSER

CSH1-001	CSH1-003	CSH1-201	CSH1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSH1-001 ENSP00000316416 ENST00000316193	P0DML2 [Direct mapping] Chorionic somatomammotropin hormone 1 A8K6C2 [Target identity:100%; Query identity:100%] Chorionic somatomammotropin hormone 1 isoform 1; HCG1749481, isoform CRA_c; HCG1749481, isoform CRA_e; HCG1749481, isoform CRA_i; cDNA FLJ75407, highly similar to Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen) (CSH1), transcript variant 1, mRNA Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0031988 [membrane-bounded vesicle] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	217 aa 25 kDa	Yes	0
CSH1-003 ENSP00000333268 ENST00000329882	A6NFB4 [Direct mapping] Chorionic somatomammotropin hormone 1; Chorionic somatomammotropin hormone 1 isoform 2; HCG1749481, isoform CRA_k Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	256 aa 28.8 kDa	Yes	0
CSH1-201 ENSP00000402517 ENST00000453363	B1A4H2 [Direct mapping] Chorionic somatomammotropin hormone 1; Chorionic somatomammotropin hormone 1 isoform 3; HCG1749481, isoform CRA_d; HCG1749481, isoform CRA_w; HCG1749481, isoform CRA_y Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	122 aa 13.9 kDa	Yes	0
CSH1-202 ENSP00000478652 ENST00000610991	A0A087WUG6 [Direct mapping] Chorionic somatomammotropin hormone 1; Chorionic somatomammotropin hormone 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	128 aa 15 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.