We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
BRIP1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BRIP1

Gene description

BRCA1 interacting protein C-terminal helicase 1

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA005474
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in colorectal cancer (favourable) and head and neck cancer (favourable).
Colorectal cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA005474

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed moderate to strong nuclear or nuclear membranous staining.

GENE INFORMATION

Gene name

BRIP1 (HGNC Symbol)

Synonyms

BACH1, FANCJ, OF

Description

BRCA1 interacting protein C-terminal helicase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.2

Chromosome location (bp)

61681266 - 61863521

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136492 (version 83.38)

Entrez gene

83990

UniProt

Q9BX63 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BX63

Antibodypedia

BRIP1 antibodies

PROTEIN BROWSER

BRIP1-001
BRIP1-002
BRIP1-003
BRIP1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRIP1-001
ENSP00000259008
ENST00000259008
Q9BX63 [Direct mapping]
Fanconi anemia group J protein
A0A024QZ45 [Target identity:100%; Query identity:100%]
BRCA1 interacting protein C-terminal helicase 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008026 [ATP-dependent helicase activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0044281 [small molecule metabolic process]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0071295 [cellular response to vitamin]
Show all
1249 aa
140.9 kDa
No 0
BRIP1-002
ENSP00000464654
ENST00000577598
J3QSE8 [Direct mapping]
Fanconi anemia group J protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0008026 [ATP-dependent helicase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
994 aa
112.5 kDa
No 0
BRIP1-003
ENSP00000462274
ENST00000577913
J3KS24 [Direct mapping]
Fanconi anemia group J protein
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
69 aa
7.5 kDa
No 0
BRIP1-006
ENSP00000463272
ENST00000584322
J3QKX0 [Direct mapping]
Fanconi anemia group J protein
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0008026 [ATP-dependent helicase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
180 aa
19.6 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.