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ACTL6A

GENERAL INFORMATION

Gene name

 ACTL6A

Gene description

 Actin-like 6A

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB012188
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012188

GENE INFORMATION

Gene name

 ACTL6A (HGNC Symbol)

Synonyms

 Actl6, Arp4, BAF53A, INO80K

Description

 Actin-like 6A (HGNC Symbol)

Entrez gene summary

 This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179562880 - 179588408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136518 (version 83.38)

Entrez gene

 86

UniProt

 O96019 (UniProt - Evidence at protein level)

neXtProt

 NX_O96019

Antibodypedia

 ACTL6A antibodies

PROTEIN BROWSER
ACTL6A-001
ACTL6A-002
ACTL6A-009
ACTL6A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTL6A-001
ENSP00000397552
ENST00000429709
O96019 [Direct mapping]
Actin-like protein 6A
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0021510 [spinal cord development]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:0090544 [BAF-type complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 429 aa
47.5 kDa 		No 0
ACTL6A-002
ENSP00000394014
ENST00000450518
O96019 [Direct mapping]
Actin-like protein 6A
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0016514 [SWI/SNF complex]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 387 aa
43.2 kDa 		No 0
ACTL6A-009
ENSP00000420153
ENST00000490364
C9JQT2 [Direct mapping]
Actin-like protein 6A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0043044 [ATP-dependent chromatin remodeling]
GO:0071564 [npBAF complex]
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 50 aa
5.5 kDa 		No 0
ACTL6A-201
ENSP00000376430
ENST00000392662
O96019 [Direct mapping]
Actin-like protein 6A
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003407 [neural retina development]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0016514 [SWI/SNF complex]
GO:0031011 [Ino80 complex]
GO:0031492 [nucleosomal DNA binding]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0071564 [npBAF complex]
GO:1903146 [regulation of mitophagy]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 387 aa
43.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.