Expression of MRPL47 in cancer - Summary - The Human Protein Atlas

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MRPL47

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MRPL47
Gene description	Mitochondrial ribosomal protein L47
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA037553
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037553

GENE INFORMATION
Gene name	MRPL47 (HGNC Symbol)
Synonyms	CGI-204, NCM1
Description	Mitochondrial ribosomal protein L47 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q26.33
Chromosome location (bp)	179588285 - 179604654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136522 (version 83.38)
Entrez gene	57129
UniProt	Q9HD33 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD33
Antibodypedia	MRPL47 antibodies

PROTEIN BROWSER

MRPL47-001	MRPL47-002	MRPL47-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL47-001 ENSP00000417602 ENST00000476781	Q9HD33 [Direct mapping] 39S ribosomal protein L47, mitochondrial Show all	Ribosomal proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003735 [structural constituent of ribosome] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	250 aa 29.5 kDa	No	0
MRPL47-002 ENSP00000259038 ENST00000259038	Q9HD33 [Direct mapping] 39S ribosomal protein L47, mitochondrial Show all	Ribosomal proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003735 [structural constituent of ribosome] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	230 aa 27.1 kDa	No	0
MRPL47-003 ENSP00000376427 ENST00000392659	Q9HD33 [Direct mapping] 39S ribosomal protein L47, mitochondrial Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003735 [structural constituent of ribosome] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005761 [mitochondrial ribosome] GO:0005762 [mitochondrial large ribosomal subunit] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0008150 [biological_process] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	140 aa 17 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.