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TBR1

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GENERAL INFORMATION

Gene name

 TBR1

Gene description

 T-box, brain, 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TBR1

Synonyms

Description

 T-box, brain, 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q24.2

Chromosome location (bp)

 161416094 - 161425870

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136535 (version 83.38)

Entrez gene

 10716

UniProt

 Q16650 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q16650

Antibodypedia

 TBR1 antibodies

PROTEIN BROWSER
TBR1-001
TBR1-002
TBR1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBR1-001
ENSP00000374205
ENST00000389554
Q16650 [Direct mapping]
T-box brain protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001661 [conditioned taste aversion]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
GO:0010092 [specification of organ identity]
GO:0010468 [regulation of gene expression]
GO:0010975 [regulation of neuron projection development]
GO:0021764 [amygdala development]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0030182 [neuron differentiation]
GO:0030902 [hindbrain development]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1902667 [regulation of axon guidance]
Show all
 682 aa
74.1 kDa 		No 0
TBR1-002
ENSP00000387023
ENST00000410035
Q16650 [Direct mapping]
T-box brain protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007420 [brain development]
Show all
 395 aa
42.3 kDa 		No 0
TBR1-006
ENSP00000393934
ENST00000411412
H7C0B1 [Direct mapping]
T-box brain protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 233 aa
25.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.