Expression of MARCH7 in cancer - Summary - The Human Protein Atlas

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MARCH7

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MARCH7
Gene description	Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA014275 , HPA022152
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014275	HPA022152

GENE INFORMATION
Gene name	MARCH7 (HGNC Symbol)
Synonyms	AXOT, MARCH-VII, RNF177
Description	Membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
Chromosome	2
Cytoband	q24.2
Chromosome location (bp)	159712457 - 159771027
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136536 (version 83.38)
Entrez gene	64844
UniProt	Q9H992 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H992
Antibodypedia	MARCH7 antibodies

PROTEIN BROWSER

MARCH7-001	MARCH7-002	MARCH7-003	MARCH7-005	MARCH7-007	MARCH7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH7-001 ENSP00000259050 ENST00000259050	Q9H992 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002643 [regulation of tolerance induction] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0042130 [negative regulation of T cell proliferation] Show all	704 aa 78.1 kDa	No	0
MARCH7-002 ENSP00000386830 ENST00000409175	Q9H992 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	704 aa 78.1 kDa	No	0
MARCH7-003 ENSP00000387238 ENST00000409591	Q9H992 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	666 aa 73.8 kDa	No	0
MARCH7-005 ENSP00000392862 ENST00000421037	C9J159 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.2 kDa	No	0
MARCH7-007 ENSP00000391493 ENST00000420397	H7BZU7 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	124 aa 14.2 kDa	No	0
MARCH7-201 ENSP00000442992 ENST00000539065	F5H6W4 [Direct mapping] E3 ubiquitin-protein ligase MARCH7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	635 aa 70.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.