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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BLK

Gene description

BLK proto-oncogene, Src family tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (Daudi, REH, RPMI-8226, U-698, U-87 MG)
HPA (normal tissue):Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in lymphatic tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
CAB005093
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB005093

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells were generally negative.

GENE INFORMATION

Gene name

BLK (HGNC Symbol)

Synonyms

MGC10442

Description

BLK proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

11494001 - 11564604

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136573 (version 83.38)

Entrez gene

640

UniProt

P51451 (UniProt - Evidence at protein level)

neXtProt

NX_P51451

Antibodypedia

BLK antibodies

PROTEIN BROWSER

BLK-001
BLK-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BLK-001
ENSP00000259089
ENST00000259089
P51451 [Direct mapping]
Tyrosine-protein kinase Blk
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032024 [positive regulation of insulin secretion]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0050853 [B cell receptor signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
505 aa
57.7 kDa
No 0
BLK-004
ENSP00000433663
ENST00000529894
E9PJX5 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030217 [T cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
434 aa
49.8 kDa
No 0

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