Fields »
ABOUT
HELP
BLOG
EPRS

GENERAL INFORMATION

Gene name

 EPRS

Gene description

 Glutamyl-prolyl-tRNA synthetase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highly abundant in endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026490 , HPA030052
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and breast cancer (unfavourable).
Urothelial cancer p<0.001
Breast cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026490
HPA030052

GENE INFORMATION

Gene name

 EPRS (HGNC Symbol)

Synonyms

 EARS, GLUPRORS, PARS, QARS, QPRS

Description

 Glutamyl-prolyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q41

Chromosome location (bp)

 219968601 - 220046658

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136628 (version 83.38)

Entrez gene

 2058

UniProt

 P07814 (UniProt - Evidence at protein level)

neXtProt

 NX_P07814

Antibodypedia

 EPRS antibodies

PROTEIN BROWSER
EPRS-001
EPRS-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPRS-001
ENSP00000355890
ENST00000366923
P07814 [Direct mapping]
Bifunctional glutamate/proline--tRNA ligase Glutamate--tRNA ligase Proline--tRNA ligase
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0004827 [proline-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0006433 [prolyl-tRNA aminoacylation]
GO:0006461 [protein complex assembly]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0017101 [aminoacyl-tRNA synthetase multienzyme complex]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0035613 [RNA stem-loop binding]
GO:0043039 [tRNA aminoacylation]
GO:0051020 [GTPase binding]
GO:0071346 [cellular response to interferon-gamma]
GO:0097452 [GAIT complex]
Show all
 1512 aa
170.6 kDa 		No 0
EPRS-007
ENSP00000477245
ENST00000609181
V9GYZ6 [Direct mapping]
Bifunctional glutamate/proline--tRNA ligase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 968 aa
109 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.