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VPS45

GENERAL INFORMATION

Gene name

 VPS45

Gene description

 Vacuolar protein sorting 45 homolog (S. cerevisiae)

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA027425 , HPA027441
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027425
HPA027441

GENE INFORMATION

Gene name

 VPS45 (HGNC Symbol)

Synonyms

 h-vps45, H1, VPS45A, VPS45B

Description

 Vacuolar protein sorting 45 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 150067293 - 150145327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136631 (version 83.38)

Entrez gene

 11311

UniProt

 Q9NRW7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRW7

Antibodypedia

 VPS45 antibodies

PROTEIN BROWSER
VPS45-001
VPS45-010
VPS45-011
VPS45-201
VPS45-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS45-001
ENSP00000358126
ENST00000369130
Q9NRW7 [Direct mapping]
Vacuolar protein sorting-associated protein 45
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007596 [blood coagulation]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
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 570 aa
65.1 kDa 		No 0
VPS45-010
ENSP00000400143
ENST00000419023
Q5T4Q0 [Direct mapping]
Vacuolar protein sorting 45 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006904 [vesicle docking involved in exocytosis]
GO:0016192 [vesicle-mediated transport]
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 316 aa
36.6 kDa 		No 0
VPS45-011
ENSP00000358124
ENST00000369128
Q9NRW7 [Direct mapping]
Vacuolar protein sorting-associated protein 45
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007596 [blood coagulation]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
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 538 aa
62 kDa 		No 0
VPS45-201
ENSP00000440690
ENST00000535106
Q9NRW7 [Direct mapping]
Vacuolar protein sorting-associated protein 45
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007596 [blood coagulation]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
 538 aa
62 kDa 		No 0
VPS45-202
ENSP00000478403
ENST00000611412
A0A087WU65 [Direct mapping]
Vacuolar protein sorting-associated protein 45
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005623 [cell]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0016192 [vesicle-mediated transport]
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 447 aa
50.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.