Fields »
ABOUT
HELP
BLOG
IL10

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 IL10

Gene description

 Interleukin 10

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (U-266/70, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/70, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IL10 (HGNC Symbol)

Synonyms

 CSIF, IL-10, IL10A, TGIF

Description

 Interleukin 10 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206767602 - 206772494

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136634 (version 83.38)

Entrez gene

 3586

UniProt

 P22301 (UniProt - Evidence at protein level)

neXtProt

 NX_P22301

Antibodypedia

 IL10 antibodies

PROTEIN BROWSER
IL10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL10-001
ENSP00000412237
ENST00000423557
P22301 [Direct mapping]
Interleukin-10
Q6FGW4 [Target identity:100%; Query identity:100%]
IL10 protein; Interleukin 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Show all
GO:0001818 [negative regulation of cytokine production]
GO:0002237 [response to molecule of bacterial origin]
GO:0002740 [negative regulation of cytokine secretion involved in immune response]
GO:0002875 [negative regulation of chronic inflammatory response to antigenic stimulus]
GO:0002904 [positive regulation of B cell apoptotic process]
GO:0005125 [cytokine activity]
GO:0005141 [interleukin-10 receptor binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007253 [cytoplasmic sequestering of NF-kappaB]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008083 [growth factor activity]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0014823 [response to activity]
GO:0014854 [response to inactivity]
GO:0030097 [hemopoiesis]
GO:0030183 [B cell differentiation]
GO:0030595 [leukocyte chemotaxis]
GO:0030886 [negative regulation of myeloid dendritic cell activation]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032496 [response to lipopolysaccharide]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032692 [negative regulation of interleukin-1 production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032701 [negative regulation of interleukin-18 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032800 [receptor biosynthetic process]
GO:0032868 [response to insulin]
GO:0034465 [response to carbon monoxide]
GO:0042092 [type 2 immune response]
GO:0042100 [B cell proliferation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042493 [response to drug]
GO:0042536 [negative regulation of tumor necrosis factor biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0042832 [defense response to protozoan]
GO:0043066 [negative regulation of apoptotic process]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045191 [regulation of isotype switching]
GO:0045347 [negative regulation of MHC class II biosynthetic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045355 [negative regulation of interferon-alpha biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050728 [negative regulation of inflammatory response]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051384 [response to glucocorticoid]
GO:0051930 [regulation of sensory perception of pain]
GO:0060302 [negative regulation of cytokine activity]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071650 [negative regulation of chemokine (C-C motif) ligand 5 production]
Show all
 178 aa
20.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.