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IL1RN

GENERAL INFORMATION

Gene name

 IL1RN

Gene description

 Interleukin 1 receptor antagonist

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A-431, HaCaT, RT4)
HPA (normal tissue):Tissue enhanced (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA001482 , CAB009633
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and testis cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Pancreatic cancer p<0.001
Testis cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA001482
CAB009633

GENE INFORMATION

Gene name

 IL1RN (HGNC Symbol)

Synonyms

 ICIL-1RA, IL-1RN, IL1F3, IL1RA, IRAP, MGC10430

Description

 Interleukin 1 receptor antagonist (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113107214 - 113134016

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136689 (version 83.38)

Entrez gene

 3557

UniProt

 P18510 (UniProt - Evidence at protein level)

neXtProt

 NX_P18510

Antibodypedia

 IL1RN antibodies

PROTEIN BROWSER
IL1RN-001
IL1RN-002
IL1RN-003
IL1RN-004
IL1RN-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL1RN-001
ENSP00000259206
ENST00000259206
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0030073 [insulin secretion]
GO:0031982 [vesicle]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 180 aa
19.9 kDa 		No 0
IL1RN-002
ENSP00000329072
ENST00000354115
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 159 aa
17.9 kDa 		No 0
IL1RN-003
ENSP00000354816
ENST00000361779
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
A0A024R528 [Target identity:100%; Query identity:100%]
Interleukin 1 receptor antagonist, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 143 aa
16.1 kDa 		No 0
IL1RN-004
ENSP00000387210
ENST00000409052
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
A0A024R528 [Target identity:100%; Query identity:100%]
Interleukin 1 receptor antagonist, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 143 aa
16.1 kDa 		No 0
IL1RN-005
ENSP00000387173
ENST00000409930
P18510 [Direct mapping]
Interleukin-1 receptor antagonist protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001660 [fever generation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005150 [interleukin-1, Type I receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005152 [interleukin-1 receptor antagonist activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006953 [acute-phase response]
GO:0006955 [immune response]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0045352 [interleukin-1 Type I receptor antagonist activity]
GO:0045353 [interleukin-1 Type II receptor antagonist activity]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:2000660 [negative regulation of interleukin-1-mediated signaling pathway]
Show all
 177 aa
20.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.