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IL36A

GENERAL INFORMATION

Gene name

 IL36A

Gene description

 Interleukin 36, alpha

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, tonsil)
GTEx:Tissue enriched (esophagus)
FANTOM5:Group enriched (esophagus, tonsil)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION

Gene name

 IL36A (HGNC Symbol)

Synonyms

 FIL1, FIL1E, IL-1F6, IL1(EPSILON), IL1F6, MGC129552, MGC129553

Description

 Interleukin 36, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113005461 - 113008044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136694 (version 83.38)

Entrez gene

 27179

UniProt

 Q9UHA7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHA7

Antibodypedia

 IL36A antibodies

PROTEIN BROWSER
IL36A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL36A-001
ENSP00000259211
ENST00000259211
Q9UHA7 [Direct mapping]
Interleukin-36 alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001819 [positive regulation of cytokine production]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0045087 [innate immune response]
Show all
 158 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.