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BIN1

GENERAL INFORMATION

Gene name

 BIN1

Gene description

 Bridging integrator 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Group enriched (cerebral cortex, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High cytoplasmic expression in CNS and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA003894 , HPA005437 , CAB001945
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003894
HPA005437
CAB001945

GENE INFORMATION

Gene name

 BIN1 (HGNC Symbol)

Synonyms

 AMPH2, AMPHL, SH3P9

Description

 Bridging integrator 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]

Chromosome

 2

Cytoband

 q14.3

Chromosome location (bp)

 127048027 - 127107355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136717 (version 83.38)

Entrez gene

 274

UniProt

 O00499 (UniProt - Evidence at protein level)

neXtProt

 NX_O00499

Antibodypedia

 BIN1 antibodies

PROTEIN BROWSER
«
BIN1-001
BIN1-002
BIN1-003
BIN1-004
BIN1-005
BIN1-006
BIN1-007
BIN1-008
BIN1-010
BIN1-011
BIN1-012
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BIN1-001
ENSP00000316779
ENST00000316724
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAF1 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_k
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 593 aa
64.7 kDa 		No 0
BIN1-002
ENSP00000350654
ENST00000357970
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAF6 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_e
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 550 aa
59.9 kDa 		No 0
BIN1-003
ENSP00000315388
ENST00000351659
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAJ3 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_i
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 506 aa
55.2 kDa 		No 0
BIN1-004
ENSP00000259238
ENST00000259238
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAJ2 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_h
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 497 aa
54.9 kDa 		No 0
BIN1-005
ENSP00000315411
ENST00000346226
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAF0 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_c
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 518 aa
56.5 kDa 		No 0
BIN1-006
ENSP00000376760
ENST00000393040
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAI5 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 482 aa
53 kDa 		No 0
BIN1-007
ENSP00000376761
ENST00000393041
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAI4 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_b
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 475 aa
51.7 kDa 		No 0
BIN1-008
ENSP00000315284
ENST00000352848
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAE9 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_d
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 454 aa
50.2 kDa 		No 0
BIN1-010
ENSP00000259237
ENST00000348750
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAI6 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_g
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 409 aa
45.6 kDa 		No 0
BIN1-011
ENSP00000386797
ENST00000409400
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAG8 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_f
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 439 aa
48.3 kDa 		No 0
BIN1-012
ENSP00000365281
ENST00000376113
O00499 [Direct mapping]
Myc box-dependent-interacting protein 1
A0A024RAG9 [Target identity:100%; Query identity:100%]
Bridging integrator 1, isoform CRA_j
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008283 [cell proliferation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030018 [Z disc]
GO:0030100 [regulation of endocytosis]
GO:0030315 [T-tubule]
GO:0030424 [axon]
GO:0031674 [I band]
GO:0033268 [node of Ranvier]
GO:0042802 [identical protein binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043194 [axon initial segment]
GO:0045664 [regulation of neuron differentiation]
GO:0048156 [tau protein binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0060987 [lipid tube]
GO:0060988 [lipid tube assembly]
GO:0070063 [RNA polymerase binding]
GO:0071156 [regulation of cell cycle arrest]
Show all
 424 aa
47.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.