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IMP4

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GENERAL INFORMATION

Gene name

 IMP4

Gene description

 IMP4, U3 small nucleolar ribonucleoprotein

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA066222 , HPA066673
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli.

Main location

 Nucleoli (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066222 MCF7 Nucleoli
HPA066222 PC-3 Nucleoli
HPA066222 U-2 OS Nucleoli
HPA066673 MCF7 Nucleoli fibrillar center
HPA066673 PC-3 Nucleoli fibrillar center
HPA066673 U-2 OS Nucleoli fibrillar center

GENE INFORMATION

Gene name

 IMP4 (HGNC Symbol)

Synonyms

 BXDC4, MGC19606

Description

 IMP4, U3 small nucleolar ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 IMP4 forms a ternary complex with IMP3 (MIM 612980) and MPP10 (MPHOSPHO10; MIM 605503) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing (Granneman et al., 2003 [PubMed 12655004]).[supplied by OMIM, Aug 2009]

Chromosome

 2

Cytoband

 q21.1

Chromosome location (bp)

 130342225 - 130347810

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136718 (version 83.38)

Entrez gene

 92856

UniProt

 Q96G21 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96G21

Antibodypedia

 IMP4 antibodies

PROTEIN BROWSER
IMP4-001
IMP4-002
IMP4-010
IMP4-012
IMP4-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IMP4-001
ENSP00000259239
ENST00000259239
Q96G21 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein IMP4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0042134 [rRNA primary transcript binding]
Show all
 291 aa
33.8 kDa 		No 0
IMP4-002
ENSP00000386411
ENST00000409935
B8ZZ47 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein IMP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006364 [rRNA processing]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0042134 [rRNA primary transcript binding]
Show all
 248 aa
28.6 kDa 		No 0
IMP4-010
ENSP00000386716
ENST00000409649
B9A008 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein IMP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006364 [rRNA processing]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0042134 [rRNA primary transcript binding]
Show all
 172 aa
19.6 kDa 		No 0
IMP4-012
ENSP00000389701
ENST00000428740
E7ENR5 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein IMP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006364 [rRNA processing]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0042134 [rRNA primary transcript binding]
Show all
 236 aa
27.1 kDa 		No 0
IMP4-014
ENSP00000409371
ENST00000452955
H0Y714 [Direct mapping]
U3 small nucleolar ribonucleoprotein protein IMP4
Show all
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006364 [rRNA processing]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034457 [Mpp10 complex]
GO:0042134 [rRNA primary transcript binding]
Show all
 280 aa
31.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.