Cell atlas - GYPC - The Human Protein Atlas

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GYPC

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Vesicles

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	GYPC
Gene description	Glycophorin C (Gerbich blood group)
Protein class	Blood group antigen proteins CD markers Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & vesicles.
RNA cell category	Cell line enhanced (SK-MEL-30, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB009445
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & vesicles.

Main location

Vesicles (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB009445	A-431	Vesicles
	CAB009445	A-431	Cytosol
	CAB009445	U-2 OS	Vesicles
	CAB009445	U-2 OS	Cytosol
	CAB009445	U-251 MG	Vesicles
	CAB009445	U-251 MG	Cytosol

GENE INFORMATION
Gene name	GYPC (HGNC Symbol)
Synonyms	CD236, CD236R, Ge, GPC, GYPD
Description	Glycophorin C (Gerbich blood group) (HGNC Symbol)
Entrez gene summary	Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Chromosome	2
Cytoband	q14.3
Chromosome location (bp)	126655933 - 126696675
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136732 (version 83.38)
Entrez gene	2995
UniProt	P04921 (UniProt - Evidence at protein level)
neXtProt	NX_P04921
Antibodypedia	GYPC antibodies

PROTEIN BROWSER

GYPC-001	GYPC-002	GYPC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYPC-001 ENSP00000259254 ENST00000259254	P04921 [Direct mapping] Glycophorin-C Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030863 [cortical cytoskeleton] Show all	128 aa 13.8 kDa	No	1
GYPC-002 ENSP00000386904 ENST00000409836	P04921 [Direct mapping] Glycophorin-C Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030863 [cortical cytoskeleton] Show all	109 aa 11.9 kDa	No	1
GYPC-201 ENSP00000349354 ENST00000356887	P04921 [Direct mapping] Glycophorin-C Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0016020 [membrane] GO:0030863 [cortical cytoskeleton] Show all	107 aa 11.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.