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GAD2

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GENERAL INFORMATION

Gene name

 GAD2

Gene description

 Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (SCLC-21H, MOLT-4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, MOLT-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GAD2 (HGNC Symbol)

Synonyms

 GAD65

Description

 Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 26216307 - 26304558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136750 (version 83.38)

Entrez gene

 2572

UniProt

 Q05329 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05329

Antibodypedia

 GAD2 antibodies

PROTEIN BROWSER
GAD2-001
GAD2-002
GAD2-003
GAD2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAD2-001
ENSP00000365437
ENST00000376261
Q05329 [Direct mapping]
Glutamate decarboxylase 2
Q5VZ30 [Target identity:100%; Query identity:100%]
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004351 [glutamate decarboxylase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006540 [glutamate decarboxylation to succinate]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0016595 [glutamate binding]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030054 [cell junction]
GO:0030170 [pyridoxal phosphate binding]
GO:0030424 [axon]
GO:0030672 [synaptic vesicle membrane]
GO:0031225 [anchored component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042493 [response to drug]
GO:0042734 [presynaptic membrane]
GO:0045202 [synapse]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0060077 [inhibitory synapse]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Show all
 585 aa
65.4 kDa 		No 0
GAD2-002
ENSP00000259271
ENST00000259271
Q05329 [Direct mapping]
Glutamate decarboxylase 2
Q5VZ30 [Target identity:100%; Query identity:100%]
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa), isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004351 [glutamate decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030054 [cell junction]
GO:0030170 [pyridoxal phosphate binding]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042734 [presynaptic membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Show all
 585 aa
65.4 kDa 		No 0
GAD2-003
ENSP00000390434
ENST00000428517
Q5VZ31 [Direct mapping]
Glutamate decarboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 188 aa
20.6 kDa 		No 0
GAD2-004
ENSP00000365424
ENST00000376248
Q5VZ29 [Direct mapping]
Glutamate decarboxylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 129 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.