Expression of YME1L1 in cancer - Summary - The Human Protein Atlas

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YME1L1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	YME1L1
Gene description	YME1-like 1 ATPase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA066953
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA066953

GENE INFORMATION
Gene name	YME1L1
Synonyms
Description	YME1-like 1 ATPase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	27110112 - 27155266
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136758 (version 83.38)
Entrez gene	10730
UniProt	Q96TA2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96TA2
Antibodypedia	YME1L1 antibodies

PROTEIN BROWSER

YME1L1-001	YME1L1-002	YME1L1-003	YME1L1-004	YME1L1-005	YME1L1-007	YME1L1-201	YME1L1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
YME1L1-001 ENSP00000398713 ENST00000427324	Q5T8D1 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	253 aa 28.3 kDa	No	1
YME1L1-002 ENSP00000473302 ENST00000477432	Q6PJ89 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1; YME1L1 protein Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.2 kDa	No	0
YME1L1-003 ENSP00000379590 ENST00000396296	Q5T8D2 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	248 aa 28.1 kDa	No	1
YME1L1-004 ENSP00000365184 ENST00000376016	Q96TA2 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0006515 [misfolded or incompletely synthesized protein catabolic process] GO:0007005 [mitochondrion organization] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	716 aa 79.8 kDa	No	1
YME1L1-005 ENSP00000318480 ENST00000326799	Q96TA2 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0006515 [misfolded or incompletely synthesized protein catabolic process] GO:0007005 [mitochondrion organization] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	773 aa 86.5 kDa	No	1
YME1L1-007 ENSP00000473557 ENST00000491542	R4GNA5 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016021 [integral component of membrane] Show all	243 aa 26.7 kDa	No	1
YME1L1-201 ENSP00000365139 ENST00000375972	Q96I63 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1; YME1-like 1 (S. cerevisiae) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005524 [ATP binding] GO:0006508 [proteolysis] GO:0016020 [membrane] Show all	740 aa 82.7 kDa	No	1
YME1L1-202 ENSP00000481724 ENST00000613434	Q96TA2 [Direct mapping] ATP-dependent zinc metalloprotease YME1L1 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] GO:0006508 [proteolysis] GO:0006515 [misfolded or incompletely synthesized protein catabolic process] GO:0007005 [mitochondrion organization] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	683 aa 76 kDa	No	1

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The Human Protein Atlas

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